Phospho-ErbB3/HER3 (Y1289) Recombinant Rabbit Monoclonal Antibody [JE51-25]

Phospho-ErbB3/HER3 (Y1289) Recombinant Rabbit Monoclonal Antibody [JE51-25]

• Description: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form which negatively regulates heregulin stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.
• Product Name Alternative: c erbB 3 antibody c erbB3 antibody Erb b2 receptor tyrosine kinase 3 antibody ErbB 3 antibody ERBB3 antibody ERBB3 protein antibody erbB3 S antibody ERBB3_HUMAN antibody Glial growth factor receptor antibody HER 3 antibody HER3 antibody Human epidermal growth factor receptor 3 antibody LCCS2 antibody MDA BF 1 antibody MGC88033 antibody p180 ErbB3 antibody p45 sErbB3 antibody p85 sErbB3 antibody proto-oncogene-like protein c ErbB 3 antibody proto-oncogene-like protein c ErbB3 antibody Proto-oncogene-like protein c-ErbB-3 antibody Receptor tyrosine protein kinase erbB 3 antibody Receptor tyrosine protein kinase erbB3 antibody Receptor tyrosine-protein kinase erbB-3 antibody Tyrosine kinase type cell surface receptor HER3 antibody Tyrosine kinase-type cell surface receptor HER3 antibody v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody
• Abbreviation: ERBB3
• CAS Number: 9000-83-3
• Swiss Prot: P21860 Human
• Cellular Locus: Cell membrane, secreted.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic phosphopeptide corresponding to a region surrounding Tyr1289 of Human ErbB3.
• Isotype: IgG
• Clone: JE51-25
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell
• Positive Control: MCF7 serum starved for 6 hours then add 10nM Neuregulin-1 for 10 minutes cell lysate, MCF7 cells serum starved for 6 hours then add 10nM Neuregulin-1 for 10 minutes.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IF-Cell: 1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 148 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes