Xanthine Oxidase Recombinant Rabbit Monoclonal Antibody [JG38-40]

Xanthine Oxidase Recombinant Rabbit Monoclonal Antibody [JG38-40]

• Description: The process of metabolizing purines to a common molecule known as xanthine is an essential process for the proper shuttling of uric acid. Xanthine oxidase is a flavoprotein enzyme that coordinates molybdenum and utilizes NAD+ as an electron acceptor to catalyze the oxidation of hypoxanthine to xanthine and then to uric acid. The predominant form of this enzyme is xanthine dehydrogenase, which is a homodimer that can be converted to xanthine oxidase by sulfhydryl oxidation or proteolytic modification. Xanthine oxidase is present in species ranging from bacteria to human and is ubiquitously expressed in mammalian tissues. In the oxidase form, this enzyme is coupled to the generation of free radicals. Individuals showing marked elevation of serum xanthine oxidase is suggestive of chronic liver disease and cholestasis, which is a condition defined by hepatic obstruction. Hepatic obstruction causes bile salts, the bile pigment bilirubin, and fats to accumulate in the blood stream instead of being eliminated normally. The clinical consequences of defects in xanthine oxidase range from mild to severe and even contribute to fatal disorders.
• Product Name Alternative: Xanthine dehydrogenase antibody Xanthine dehydrogenase/oxidase antibody Xanthine oxidase antibody Xanthine oxidoreductase antibody XD antibody XDH antibody XDH_HUMAN antibody xdha antibody XO antibody xor antibody
• Abbreviation: XD, XO, XOR, XDH, XDHA
• CAS Number: 9000-83-3
• Swiss Prot: P47989 Human, Q00519 Mouse, P22985 Rat
• Cellular Locus: Cytoplasm. Peroxisome. Secreted.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human Xanthine Oxidase aa 182-313 / 1333.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: Human kidney tissue lysates, rat liver tissue, human liver tissue, mouse liver tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 146 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes