STUB1 Recombinant Rabbit Monoclonal Antibody [JG38-22]

• Description:

  CHIP (carboxy terminus of HSP 70-interacting protein), also designated STIP1 homology and U-box containing protein 1, HSPABP2, NY-CO-7, SDCCAG7 and STUB1, is a cytoplasmic E3 ubiquitin ligase that influences protein ubiquitylation. CHIP interacts with Smad1/Smad4 and blocks BMP signaling through the ubiquitin-mediated degradation of Smad proteins. CHIP controls both association of Hsp70/Hsp90 chaperones with ErbB2 and down-regulation of ErbB2 induced by inhibitors of Hsp90. A 1.3-kb transcript is most abundant in striated muscle (heart and skeletal muscle), with lower expression in pancreas and brain.

• Product Name Alternative:

  Antigen NY CO 7 antibody Antigen NY-CO-7 antibody C terminus of Hsp70-interacting protein antibody Carboxy terminus of Hsp70 interacting protein antibody Carboxy terminus of Hsp70-interacting protein antibody Carboxy terminus of Hsp70p interacting protein antibody CHIP antibody CHIP_HUMAN antibody CLL associated antigen KW 8 antibody CLL-associated antigen KW-8 antibody E3 ubiquitin protein ligase CHIP antibody E3 ubiquitin-protein ligase CHIP antibody Heat shock protein A binding protein 2 (c terminal) antibody HSPABP2 antibody NY CO 7 antibody PP1131 antibody SDCCAG7 antibody Serologically defined colon cancer antigen 7 antibody STIP1 homology and U Box containing protein 1 antibody STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase antibody STIP1 homology and U box-containing protein 1 antibody STUB 1 antibody STUB1 antibody UBOX 1 antibody UBOX1 antibody

• Abbreviation:

  STUB1, CHIP, PP1131

• Swiss Prot:

  Q9UNE7 Human, Q9WUD1 Mouse,

• Cellular Locus:

  Nucleus. Cytoplasm.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide within Human STUB1 aa 10-59 / 303.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  WB, IF-Cell, IHC-P, IP, FC

• Positive Control:

  HeLa cell lysate, HEK-293 cell lysate, human brain tissue lysate, human heart tissue, mouse heart tissue, rat heart tissue, 293T, LOVO, MCF-7, SH-SY5Y.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:1,000-1:2,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 35 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3