SENP1 Recombinant Rabbit Monoclonal Antibody [JG37-79]

• Description:

  Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1. Deconjugates SUMO1 from GPS2.

• Product Name Alternative:

  SENP 1 antibody SENP1 antibody SENP1_HUMAN antibody Sentrin specific protease 1 antibody Sentrin-specific protease 1 antibody Sentrin/SUMO specific protease 1 antibody Sentrin/SUMO specific protease antibody Sentrin/SUMO specific protease SENP 1 antibody Sentrin/SUMO specific protease SENP1 antibody Sentrin/SUMO-specific protease SENP1 antibody SUMO1/sentrin specific peptidase 1 antibody SUMO1/sentrin specific protease 1 antibody SuPr 2 antibody SuPr2 antibody

• Abbreviation:

  SENP1

• Swiss Prot:

  Q9P0U3 Human

• Cellular Locus:

  Cytoplasm. Nucleus.

• Host:

  Rabbit

• Species Reactivity:

  Human

• Immunogen:

  Recombinant protein within Human SENP1 aa 380-521 / 644.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  WB, IF-Cell, IF-Tissue, IHC-P, FC

• Positive Control:

  K562 cell lysates, LOVO, SH-SY-5Y, SiHa, human liver tissue, human small Intestine tissue, Daudi.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:1,000-1:2,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  73 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3