Nuclear Matrix Protein p84 Recombinant Rabbit Monoclonal Antibody [JU53-18]

Nuclear Matrix Protein p84 Recombinant Rabbit Monoclonal Antibody [JU53-18]

• Description: THOC1 (THO complex subunit 1), also known as Tho1, P84, HPR1 or P84N5, is a 657 amino acid nuclear matrix protein and is evolutionarily conserved from yeast to humans. THOC1 contains one death domain and is a component of the heteromultimeric THO/TREX (transcription/export) complex along with THOC2, THOC3, BAT1 and ALY. The THO/TREX complex is recruited to transcribed genes and travels along with RNA polymerase II (Pol II) during elongation, coupling elongating Pol II with RNA splicing and export factors. THOC1 is expressed at high levels in breast cancer cells and at relatively low levels in normal epithelia. A reduction of THOC1 in cancer cell lines results in reduced cell proliferation. This suggests that cancer cells are dependent on the high levels of THOC1 expression and therefore THOC1 may be a good target for cancer therapy.
• Product Name Alternative: hTREX84 antibody Death domain containing protein p84N5 antibody HPR 1 antibody HPR1 antibody hTREX84 antibody Nuclear matrix protein p84 antibody P84 antibody p84N5 antibody Tho 1 antibody THO complex 1 antibody THO complex subunit 1 antibody Tho1 antibody THOC 1 antibody Thoc1 antibody THOC1_HUMAN antibody
• Abbreviation: Tho1, p84N5, THOC1, HPR1
• CAS Number: 9000-83-3
• Swiss Prot: Q96FV9 Human, Q8R3N6 Mouse, P59924 Rat
• Cellular Locus: Nucleus speckle,Nucleus, nucleoplasm,Nucleus matrix,Cytoplasm
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human Nuclear Matrix Protein p84 aa 367-416 / 657.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P
• Positive Control: Hela cell lysate, A431 cell lysate, Mouse skeletal muscle lysate, PC-12 cell lysate, HUVEC, LOVO, rat testis tissue, rat brain tissue, human colon carcinoma tissue, human tonsil tissue, human lung carcinoma tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 76 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes