PML Protein Rabbit Polyclonal Antibody

• Description:

  Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin of the cell nucleus. These nuclear bodies are present in mammalian nuclei, at about 1 to 30 per cell nucleus. PML-NBs are known to have a number of regulatory cellular functions, including involvement in programmed cell death, genome stability, antiviral effects and controlling cell division. PML mutation or loss, and the subsequent dysregulation of these processes, has been implicated in a variety of cancers.

• Product Name Alternative:

  Acure promyelocytic leukemia, inducer of antibody MYL antibody Pml antibody PML_HUMAN antibody PP8675 antibody Probable transcription factor PML antibody Promyelocytic leukemia antibody Promyelocytic leukemia inducer of antibody Promyelocytic leukemia protein antibody Protein PML antibody RING finger protein 71 antibody RNF 71 antibody RNF71 antibody TRIM 19 antibody Tripartite motif protein TRIM19 antibody Tripartite motif-containing protein 19 antibody

• Abbreviation:

  PML, MYL, PP8675, RNF71, TRIM19

• Swiss Prot:

  P29590 Human, Q60953 Mouse,

• Cellular Locus:

  Nucleus, Cytoplasm, PML body, nucleolus, Endoplasmic reticulum membrane, Early endosome membrane.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein within human PML Protein aa 1-600 / 882.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IF-Cell, IHC-P, FC

• Positive Control:

  HeLa cell lysate, HEK-293 cell lysate, K-562 cell lysate, A549 cell lysate, MDA-MB-231 cell lysate, A431 cell lysate, human kidney tissue lysate, MDA-MB-231, A431, human brain tissue, human breast tissue, human breast cancer tissue, human testis tissue, mouse breast tissue, rat breast tissue.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:2,000 ;IF-Cell: 1:100 ;IHC-P: 1:1,000 ;FC: 1:1,000

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 98 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4