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Higenamine (hydrochloride)

CAT: 0804-HY-N2037A-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2037A-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases[1][2][3][4][5][6].
CAS Number
11041-94-4
Product Name Alternative
Norcoclaurine (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; MAP3K; MDM-2/p53; ROS Kinase
Type
Natural Products
Related Pathways
Apoptosis; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/higenamine-hydrochloride.html
Purity
99.52
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)
Smiles
OC1=CC2=C(C(CC3=CC=C(O)C=C3)NCC2)C=C1O.[H]Cl
Molecular Formula
C16H18ClNO3
Molecular Weight
307.77
Precautions
H302, H315, H319, H335
References & Citations
[1]Fang Y, et al. Discovery of higenamine as a potent, selective and cellular active natural LSD1 inhibitor for MLL-rearranged leukemia therapy. Bioorg Chem. 2021 Apr;109:104723. |[2]Ha YM, et al. Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways. Apoptosis. 2012 May;17 (5) :463-74.|[3]Zhu X, et al. Higenamine mitigates interleukin-1β-induced human nucleus pulposus cell apoptosis by ROS-mediated PI3K/Akt signaling. Mol Cell Biochem. 2021 Nov;476 (11) :3889-3897.|[4]Deng T, et al. Higenamine Improves Cardiac and Renal Fibrosis in Rats With Cardiorenal Syndrome via ASK1 Signaling Pathway. J Cardiovasc Pharmacol. 2020 Jun;75 (6) :535-544. |[5] Erasto, Paul et al. Evaluation of Antimycobacterial Activity of Higenamine Using Galleria mellonella as an In Vivo Infection Model. Natural products and bioprospecting vol. 8,1 (2018) : 63-69. |[6]Dong, Hui et al. Higenamine Promotes Osteogenesis Via IQGAP1/SMAD4 Signaling Pathway and Prevents Age- and Estrogen-Dependent Bone Loss in Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol. 38,5 (2023) : 775-791.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
Phase 1
Isoform
MAP3K5/ASK1; β adrenergic receptor
Citation 01
Arch Toxicol. 2025 May;99 (5) :1999-2021.|Cell. 2025 Sep 18;188 (19) :5142-5156.e23.|J Inflamm Res. 2024 Oct 14:17:7295-7310.|Nutrients. 2024 May 22.|Food Sci Hum Wellness. 2025.|J Pharm Biomed Anal. 2021 Feb 20:195:113870.

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