DNA Polymerase beta Recombinant Rabbit Monoclonal Antibody [JM93-12]

DNA Polymerase beta Recombinant Rabbit Monoclonal Antibody [JM93-12]

• Description: DNA polymerase beta, also known as POLB, is an enzyme present in eukaryotes. In humans, it is encoded by the POLB gene. In eukaryotic cells, DNA polymerase beta (POLB) performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance. The mitochondrial DNA of mammalian cells is constantly under attack from oxygen radicals released during ATP production. Mammalian cell mitochondria contain an efficient base excision repair system employing POLB that removes some frequent oxidative DNA damages. POLB thus has a key role in maintaining the stability of the mitochondrial genome. An analysis of the fidelity of DNA replication by polymerase beta in the neurons from young and very aged mice indicated that aging has no significant effect on the fidelity of DNA synthesis by polymerase beta. This finding was considered to provide evidence against the error catastrophe theory of aging.
• Product Name Alternative: DNA directed DNA polymerase beta antibody DNA pol beta antibody DNA polymerase beta antibody DNA polymerase beta subunit antibody DPOLB_HUMAN antibody MGC125976 antibody Pol B antibody Pol beta antibody POLB antibody Polymerase (DNA directed) beta antibody
• Abbreviation: POLB
• CAS Number: 9000-83-3
• Swiss Prot: P06746 Human, Q8K409 Mouse, P06766 Rat
• Cellular Locus: Nucleus, Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat, Zebrafish
• Immunogen: Synthetic peptide within Human DNA Polymerase beta aa 286-335 / 335.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, IF-Cell, IP
• Positive Control: PC-12 cell lysate, NIH/3T3 cell lysate, A431 cell lysate, zebrafish tissue lysates, rat lung tissue, human breast carcinoma tissue, human stomach carcinoma tissue, human uterus tissue, mouse cerebellum tissue, K-562.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500 ;IHC-P: 1:50-1:200 ;IF-Cell: 1:20-1:50 ;IP: 1:10-1:20
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 38 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes