Myelin Basic Protein Recombinant Rabbit Monoclonal Antibody [JF0943]

Myelin Basic Protein Recombinant Rabbit Monoclonal Antibody [JF0943]

• Description: Myelin basic protein (MBP) is the major extrinsic membrane protein of central nervous system myelin. MBP phosphorylation at Threonine 125 is a complex regulatory process that modulates the contribution of MBP to the stability of the myelin sheath. Mitogen-activated protein kinases modulate MBP phosphorylation during myelinogenesis and in the demyelinating disease multiple sclerosis. MBP phosphorylation is regulated by high-frequency stimulation but not low-frequency stimulation of the alveus, the myelinated output fibers of the hippocampus. It is proposed that during periods of increased neuronal activity, calcium activates axonal nitric oxide synthase, which generates the intercellular messengers nitric oxide and superoxide and regulates the phosphorylation state of MBP by MAPK.
• Product Name Alternative: GDB antibody Golli MBP antibody Golli MBP; myelin basic protein antibody Hemopoietic MBP antibody HMBPR antibody HUGO antibody MBP antibody MBP_CAVPO antibody MBP_HUMAN antibody MGC99675 antibody MLD antibody Myelin A1 protein antibody Myelin A1 Protein, basic antibody Myelin basic protein antibody Myelin Deficient antibody Myelin membrane encephalitogenic protein antibody OTTHUMP00000163776 antibody OTTHUMP00000174387 antibody OTTHUMP00000174388 antibody SHI antibody Shiverer antibody SP antibody
• Abbreviation: MBP
• CAS Number: 9000-83-3
• Swiss Prot: P02686 Human, P04370 Mouse, P02688 Rat
• Cellular Locus: Myelin membrane, Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human Myelin Basic Protein aa 121-304 / 304.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, IF-Tissue, IHC-Fr
• Positive Control: Rat brain tissue lysate, Mouse brain tissue lysate, human brain tissue, mouse brain tissue, rat brain tissue, mouse cerebral cortex tissue, mouse hippocampus tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:1,000 ;IF-Tissue: 1:200 ;IHC-Fr: 1:200-1:500
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 33 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes