AMPK beta 1 Recombinant Rabbit Monoclonal Antibody [SD082-06]

AMPK beta 1 Recombinant Rabbit Monoclonal Antibody [SD082-06]

• Description: AMPK (for 5'-AMP-activated protein kinase) is a heterotrimeric complex com-prising a catalytic α subunit and regulatory β and γ subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming bio-synthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase, and inhibition of dephosphorylation. Activated AMPK can phosphorylate and regulate in vivo hydroxy-methylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively. The human AMPKα1 and AMPKα2 genes encode 548 amino acid and 552 amino acid proteins, respectively. Human AMPKβ1 encodes a 271 amino acid protein and human AMPKβ2 encodes a 272 amino acid protein. The human AMPKγ1 gene encodes a 331 amino acid protein. Human AMPKγ2 and AMPKγ3, which are 569 and 492 amino acid proteins, respectively, contain unique N-terminal domains and may participate directly in the binding of AMP within the AMPK complex.
• Product Name Alternative: 1300015D22Rik antibody 5'-AMP-activated protein kinase subunit beta-1 antibody 5'-AMP-activated protein kinase beta-1 subunit antibody AAKB1_HUMAN antibody AMP-activated protein kinase beta subunit antibody AMP-ACTIVATED PROTEIN KINASE, NONCATALYTIC, BETA-1 antibody AMP-activated, noncatalytic, beta-1 antibody AMPK antibody AMPK beta 1 chain antibody AMPK subunit beta-1 antibody AMPK-BETA-1 antibody AMPKb antibody AU021155 antibody E430008F22 antibody HAMPKb antibody MGC17785 antibody PRKAB1 antibody Protein kinase AMP activated non catalytic subunit beta 1 antibody protein kinase, AMP-activated, beta 1 non-catalytic subunit antibody protein kinase, AMP-activated, noncatalytic, beta-1 antibody
• Abbreviation: AMPK subunit beta-1, AMPKb, PRKAB1
• CAS Number: 9000-83-3
• Swiss Prot: Q9Y478 Human, Q9R078 Mouse, P80386 Rat
• Cellular Locus: Cytosol, nucleoplasm, nucleus, cytoplasm, nucleotide-activated protein kinase complex.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within human AMPK beta 1 aa 90-130.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, FC, IF-Cell
• Positive Control: HeLa cell lysate, A431 cell lysate, C2C12 cell lysate, NIH/3T3 cell lysate, rat brain tissue lysate, human smooth muscle tissue, A431, C2C12.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IF-Cell: 1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 30 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes