Tuberin Recombinant Rabbit Monoclonal Antibody [SC05-59]

Tuberin Recombinant Rabbit Monoclonal Antibody [SC05-59]

• Description: Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by mental retardation and the widespread development of distinctive tumors termed hamartomas. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein called tuberin and the other loci, tuberous sclerosis-1 gene (TSC1), encodes a protein called hamartin. Tuberin and hamartin interact with each other forming a cystoplasmic complex. Hamartin interacts with the ezrin-radixin-moesin (ERM) family of actin-binding proteins and inhibition of hamartin activity results in loss of cell adhesion. Hamartin is present in most adult tissues with strong expression in brain, heart, and kidney.
• Product Name Alternative: FLJ43106 antibody LAM antibody OTTHUMP00000158940 antibody OTTHUMP00000198394 antibody OTTHUMP00000198395 antibody PPP1R160 antibody Protein phosphatase 1, regulatory subunit 160 antibody tsc2 antibody TSC2_HUMAN antibody TSC4 antibody TSC4 gene, formerly antibody TSC4, formerly antibody Tuberin antibody Tuberous sclerosis 2 antibody Tuberous sclerosis 2 protein antibody Tuberous sclerosis 2 protein homolog antibody
• Abbreviation: TSC2, TSC4
• CAS Number: 9000-83-3
• Swiss Prot: P49815 Human, Q61037 Mouse, P49816 Rat
• Cellular Locus: Cytoplasm, Membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human Tuberin aa 1760-1807 / 1807.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, FC
• Positive Control: HEK-293 cell lysate, HeLa cell lysate, LNCaP cell lysate, C6 cell lysate, Mouse brain tissue lysate, Rat brain tissue lysate, human testis tissue, mouse testis tissue, rat testis tissue, HeLa.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000 ;IHC-P: 1:200 ;FC: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 201 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes