beta Arrestin 1 Recombinant Rabbit Monoclonal Antibody [ST51-08]

beta Arrestin 1 Recombinant Rabbit Monoclonal Antibody [ST51-08]

• Description: The members of the G protein coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. Members of theβ-Arrestin family regulate receptor binding to G proteins. β-Arrestins have been found to be located at postsynaptic sites, where they are thought to act in concert withβARK (βARK1, also designated GRK 2, orβARK2, also designated GRK 3 to regulate G protein-coupled neurotransmitter receptors. Expression ofβ-Arrestin-1 and b-Arrestin-2 is seen predominantly in spleen and neuronal tissues. It has been shown thatβ-Arrestin-1 expression is modulated by intracellular cAMP, which may be a novel mechanism for the regulation of receptor-mediated responses.
• Product Name Alternative: ARB1 antibody ARR1 antibody ARRB1 antibody ARRB1_HUMAN antibody Arrestin 2 antibody Arrestin beta 1 antibody Arrestin beta-1 antibody Beta-arrestin-1 antibody
• Abbreviation: ARRB1, ARR1
• CAS Number: 9000-83-3
• Swiss Prot: P49407 Human, Q8BWG8 Mouse, P29066 Rat
• Cellular Locus: Cell membrane, Cell projection, Coated pit, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human beta Arrestin 1 aa 1-50 / 418.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Tissue, IHC-P, IP
• Positive Control: K-562 cell lysate, RAW264.7 cell lysate, PC-12 cell lysate, Mouse lung tissue lysate, Rat brain tissue lysate, Rat lung tissue lysate, human brain tissue, human lung tissue, mouse brain tissue, mouse lung tissue, rat brain tissue, rat lung tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:2,000 ;IF-Tissue: 1:50 ;IHC-P: 1:200 ;IP: Use at an assay dependent concentration.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 47 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes