LXR beta Recombinant Rabbit Monoclonal Antibody [PSH0-56]

LXR beta Recombinant Rabbit Monoclonal Antibody [PSH0-56]

• Description: Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2). The liver X receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA) and beta, are known to encode LXR proteins. Crystal structure of human liver X receptor β (LXRβ) forming heterodimer with its partner retinoid X receptor α (RXRα) on its cognate element, an AGGTCA direct repeat spaced by 4 nt shows an extended X-shaped arrangement, with DNA- and ligand-binding domains crossed. The LXRβ core binds DNA via canonical contacts and auxiliary DNA contacts that enhance affinity for the response element. Liver X receptor beta has been shown to interact with NCOA6[8] and Retinoid X receptor alpha.
• Product Name Alternative: Liver X nuclear receptor beta antibody Liver X receptor beta antibody LX receptor beta antibody LXR b antibody LXR beta antibody LXRB antibody NER antibody NER I antibody NER1 antibody NR1H 2 antibody NR1H2 antibody NR1H2_HUMAN antibody Nuclear orphan receptor LXR beta antibody Nuclear receptor NER antibody Nuclear receptor subfamily 1 group H member 2 antibody OR-1 antibody Oxysterols receptor LXR-beta antibody RIP15 antibody Steroid hormone nuclear receptor NER antibody Ubiquitously-expressed nuclear receptor antibody UNR antibody
• Abbreviation: NR1H2, LXRB, NER, UNR
• CAS Number: 9000-83-3
• Swiss Prot: P55055 Human, Q60644 Mouse, Q62755 Rat
• Cellular Locus: Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within human LXR beta aa 50-100/460.
• Isotype: IgG
• Clone: PSH0-56
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell
• Positive Control: SW480 cell lysate, HepG2 cell lysate, PC-3M cell lysate, A549 cell lysate, HeLa cell lysate, HT-29 cell lysate, HCT116 cell lysate, HEK-293 cell lysate, mouse brain tissue lysate, mouse liver tissue lysate, rat liver tissue lysate, C2C12, HCT116.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IF-Cell: 1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 51 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes