Phospho-V-Myb+C-Myb (S11) Recombinant Rabbit Monoclonal Antibody [SZ04-81]

Phospho-V-Myb+C-Myb (S11) Recombinant Rabbit Monoclonal Antibody [SZ04-81]

• Description: The Myb family of transcription factors regulates proliferation, differentiation and apoptosis of hematopoletic cells. The avian myeloblastosis viral (v-Myb) protein is nuclear and binds to specific DNA sequences. The gene encoding for v-Myb is oncogenic, causing monoblastic leukemia and transforming myelomonocytic cells by deregulating the expression of specific target genes. v-Myb functions as a transcriptional activator, and it can repress biologically relevant genes such as Ets-2, which promotes macrophage differentiation. The proto-oncogene c-Myb encodes for a nuclear protein that plays a role in transcriptional regulation and may be essential for hematopoietic cell proliferation. A-Myb is also member of the Myb family that is expressed in proliferating B cell centroblasts. Transgenic mice overexpressing A-Myb posses enhanced hyperplasia of the lymph nodes.
• Product Name Alternative: C myb antibody C myb protein antibody Cmyb antibody MYB antibody Myb proto oncogene antibody V myb myeloblastosis viral oncogene homolog antibody
• Abbreviation: MYB
• CAS Number: 9000-83-3
• Swiss Prot: P10242 Human
• Cellular Locus: Nucleus, cytosol.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser11 of Human V-Myb+C-Myb.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: IF-Cell, IF-Tissue, IHC-P
• Positive Control: AGS, human tonsil tissue, MCF-7.
• Concentration: 1 mg/mL
• Dilution: IF-Cell: 1:100 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:200-1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 72 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes