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eIF-6 Rabbit Polyclonal Antibody

CAT: 0992-ER2001-54Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER2001-54Size:100 µL
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Description
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC . Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity).
CAS Number
9007-83-4
Product Name Alternative
b (2)gcn antibody B (2)GCN homolog antibody B4 integrin interactor antibody Binding protein of beta-4 integrin antibody CAB antibody eIF-6 antibody EIF3A antibody EIF6 antibody Eukaryotic translation initiation factor 3A antibody Eukaryotic translation initiation factor 6 antibody IF6_HUMAN antibody Integrin beta 4 binding protein antibody ITGB4BP antibody OK/SW-cl.27 antibody p27 beta 4 integrin binding protein antibody p27 (BBP) antibody p27BBP antibody RP4-614O4.1 antibody
Abbreviation
Eukaryotic translation initiation factor 6 eIF-6 B (2)GCN homolog B4 integrin interactor CAB p27 (BBP)
Swiss Prot
P56537 Human, O55135 Mouse
Cellular Locus
Centromere, Chromosome, Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant protein within human eIF-6 aa 1-200.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
SHSY5Y cell lysate, A549 cell lysate, HepG2 cell lysate, human colon tissue, mouse colon tissue, SW620.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000;IHC-P: 1:500-1:2,000;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
26 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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