BCL-6 Rabbit Polyclonal Antibody

Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4+ T-cells (T (FH) cells), promotes the expression of T (FH)-related genes but inhibits the differentiation of T (H)1, T (H)2 and T (H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2.

9007-83-4

B cell CLL/lymphoma 6 antibody B cell lymphoma 6 protein antibody B-cell lymphoma 5 protein antibody B-cell lymphoma 6 protein antibody BCL 5 antibody Bcl 6 antibody BCL-5 antibody BCL-6 antibody BCL5 antibody BCL6 antibody BCL6_HUMAN antibody BCL6A antibody cys his2 zinc finger transcription factor antibody cys-his2 zinc finger transcription factor antibody LAZ 3 antibody LAZ 3 protein antibody LAZ3 antibody Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3) antibody Lymphoma associated zinc finger gene on chromosome 3 antibody Protein LAZ-3 antibody ZBTB 27 antibody ZBTB27 antibody Zinc finger and BTB domain containing protein 27 antibody Zinc finger and BTB domain-containing protein 27 (ZBTB27) antibody Zinc finger and BTB domain-containing protein 27 antibody Zinc Finger Protein 51 (ZNF51) antibody Zinc finger protein 51 antibody zinc finger transcription factor BCL6S antibody ZNF 51 antibody ZNF51 antibody

BCL-6,B-cell lymphoma 6 protein,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51,BCL6

P41182 Human

Nucleus.

Recombinant protein within Human BCL-6 aa 287-464 / 706.

Non-conjugated

Rabbit polyclonal Antibody

WB, IF-Cell, FC

Raji cell lysates, HepG2, Jurkat.

1 mg/mL

WB: 1:500-1:2000;IF-Cell: 1:50-1:200;FC: 1:50-1:100

Immunogen affinity purified.

Liquid

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

79 kDa

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.