IL-22 Rabbit Polyclonal Antibody

IL-22 Rabbit Polyclonal Antibody

• Description: IL-22 a member of a group of cytokines called the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. It shares use of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28A/B and IL-29. IL-22 is produced by activated NK and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 is rapidly produced by splenic LTi-like cells and also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive innate immune systems, autoimmunity and tissue regeneration. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S100s and defensins. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. In some contexts, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by the often co-expressed cytokine IL-17A.
• Product Name Alternative: Cytokine Zcyto18 antibody IL 10 related T cell derived inducible factor antibody IL 21 antibody IL 22 antibody IL D110 antibody IL TIF antibody IL-10-related T-cell-derived-inducible factor antibody IL-22 antibody IL-TIF antibody IL21 antibody Il22 antibody IL22_HUMAN antibody ILD110 antibody ILTIF antibody Interleukin 10 related T cell derived inducible factor antibody interleukin 21 antibody Interleukin 22 antibody Interleukin-22 antibody MGC79382 antibody MGC79384 antibody TIFa antibody TIFIL 23 antibody TIFIL23 antibody UNQ3099/PRO10096 antibody zcyto18 antibody
• Abbreviation: IL-22, IL-TIF, IL22, ILTIF, ZCYTO18
• CAS Number: 9007-83-4
• Swiss Prot: Q9GZX6 Human, Q9JJY9 Mouse,
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within human IL-22 aa 34-179.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: ELISA, WB, IHC-P
• Positive Control: Rat kidney tissue, human tonsil tissue, human breast cancer tissue, mouse colon tissue.
• Concentration: 1 mg/mL
• Dilution: ELISA:1:5000-1:10,000 ;WB:1:500 ;;;;IHC-P:1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 20 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No