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BAX Rabbit Polyclonal Antibody

CAT: 0992-ER0907Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER0907Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAX is a member of the Bcl-2 gene family. Apoptosis regulator BAX promotes apoptosis by binding to and antagonizing the Bcl-2 protein. In healthy mammalian cells, the majority of BAX is found in the cytosol, but upon initiation of apoptotic signaling, Bax undergoes a conformational shift. Upon induction of apoptosis, BAX becomes organelle membrane-associated, and in particular, mitochondrial membrane associated. The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis. The p53 protein is a transcription factor that, when activated as part of the cell's response to stress, regulates many downstream target genes, including BAX.
CAS Number
9007-83-4
Product Name Alternative
Apoptosis regulator BAX antibody BAX antibody Bax-protein antibody BAX_HUMAN antibody BAXA antibody Baxdelta2G9 antibody Baxdelta2G9omega antibody Baxdelta2omega antibody Bcl-2-like protein 4 antibody BCL2 associated X protein antibody BCL2 associated X protein omega antibody BCL2 associated X protein transcript variant delta2 antibody Bcl2-L-4 antibody BCL2L4 antibody membrane isoform alpha antibody
Abbreviation
Bcl2-L-4
Swiss Prot
Q07812 Human, Q07813 Mouse, Q63690 Rat
Cellular Locus
Mitochondrion membrane, cytoplasm.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within Human BAX aa 1-50 / 192.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
HeLa cell lysate, MCF7 cell lysate, HEK-293 cell lysate, Daudi cell lysate, Raji cell lysate, Jurkat cell lysate, HepG2, F9, SHSY5Y, human colon carcinoma tissue, mouse kidney tissue.
Concentration
1 mg/mL
Dilution
WB: 1:5,000-1:20,000 ;IF-Cell: 1:200 ;IHC-P: 1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 21 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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