MUC5AC Mouse Monoclonal Antibody [A3H3]

MUC5AC Mouse Monoclonal Antibody [A3H3]

• Description: Mucins are a group of high molecular weight glycoproteins consisting of a mucin core protein and O-linked carbohydrates. Mucin 6 carries GlcNAca1-->4Galb-->R structures, indicating that alpha1, 4-N-acetylglucosaminyltransferase is important to the formation of the mucous glycoproteins in vivo. Mucin 5AC is a gel-forming mucin that is secreted from surface mucous cells. Glucocorticoid is required for the expression of Mucin 5AC mRNA and high doses of hydrocortisone suppress its expression. Additionally, asthmatic fluid stimulates Mucin 5AC synthesis several-fold. The pro-inflammatory cytokines IL-6 and TNF-alpha stimulate Mucin 5AC secretion and thus contribute to the upregulation of mucin by chronic inflammation. Expression of Mucin 5AC is retinoic acid (RA)- or retinol- dependent and RA control of mucin genes is mediated by the retinoid acid receptor RARα and, to a lesser extent, by RARγ. Thyroid hormone binding to thyroid receptors inhibits Mucin 5AC gene expression. Mucin 5AC is also expressed in normal endocervical epithelium, small intestine, gastric cells (Lewis type 1) and gastric metaplasia, and it is a one of the major mucins in the ethmoid mucosa.
• Product Name Alternative: Apomucin antibody Apomucin Major Airway Glycoprotein antibody Gastric mucin antibody LeB antibody Lewis B blood group antigen antibody Major Airway Glycoprotein antibody MUC 5 antibody MUC5 antibody MUC5AC antibody Mucin 5 subtype AC tracheobronchial antibody Mucin 5 Subtypes A And C antibody Mucin 5 subtypes A and C tracheobronchial/gastric antibody Mucin 5, tracheobronchial/gastric antibody Mucin 5AC antibody Mucin 5AC oligomeric mucus/gel forming antibody Mucin 5AC, oligomeric mucus/gel forming pseudogene antibody Mucin antibody TBM antibody Tracheobronchial Mucin (TBM) antibody Tracheobronchial mucin antibody
• Abbreviation: Mucin-5AC MUC-5AC TBM MUC5AC MUC5
• CAS Number: 9007-83-4
• Swiss Prot: P98088 Human
• Cellular Locus: Secreted.
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Recombinant protein within Human MUC5AC aa 600-850.
• Isotype: IgG1
• Conjugation: Non-conjugated
• Type: Mouse monoclonal Antibody
• Applications: IHC-P, FC
• Positive Control: Human stomach tissue, A549.
• Concentration: 2 mg/mL
• Dilution: IHC-P: 1:1,000 ;FC: 1:50-1:200
• Purity: Protein G affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 586 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No