DNMT1 Mouse Monoclonal Antibody [A3A9]

DNMT1 Mouse Monoclonal Antibody [A3A9]

• Description: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. Promotes tumor growth.
• Product Name Alternative: ADCADN antibody AIM antibody CXXC finger protein 9 antibody CXXC-type zinc finger protein 9 antibody CXXC9 antibody DNA (cytosine 5 ) methyltransferase 1 antibody DNA (cytosine-5)-methyltransferase 1 antibody DNA methyltransferase 1 antibody DNA methyltransferase HsaI antibody DNA methyltransferase M.HsaI. antibody DNA MTase antibody DNA MTase HsaI antibody DNMT 1 antibody DNMT antibody Dnmt1 antibody DNMT1_HUMAN antibody Dnmt1o antibody FLJ16293 antibody HSN1E antibody M.HsaI antibody MCMT antibody Met1 antibody MGC104992 antibody mMmul antibody MommeD2 antibody
• Abbreviation: DNMT1
• CAS Number: 9007-83-4
• Swiss Prot: P26358 Human
• Cellular Locus: Nucleus.
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Synthetic peptide within Human Dnmt1 aa 500-600 / 1616.
• Isotype: IgG1
• Conjugation: Non-conjugated
• Type: Mouse monoclonal Antibody
• Applications: WB, IHC-P, FC
• Positive Control: Daudi cell lysate, 293 cell lysate, human tonsil tissue, JAR.
• Concentration: 2 mg/mL
• Dilution: WB:1:500-1:1,000 ;IHC-P:1:50-1:200 ;FC:1:50-1:100
• Purity: Protein G affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 183 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No