DFNA5 / GSDME Mouse Monoclonal Antibody [A1H2]

DFNA5 / GSDME Mouse Monoclonal Antibody [A1H2]

• Description: Non-syndromic hearing impairment protein 5 is a protein that in humans is encoded by the DFNA5 gene. Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. The observation that DFNA5 is epigenetically inactivated in a large number of cancers of frequent types (gastric, colorectal, and breast) is another important finding and is in line with its apoptosis-inducing properties. Indeed, if apoptosis is an intrinsic feature of DFNA5, shutting the gene down in tumor cells makes them more susceptible to uncontrolled cellular growth. Moreover, the fact that DFNA5 is regulated by P53 strongly suggests that DFNA5 is a tumor suppressor gene.
• Product Name Alternative: 2310037D07Rik antibody 4932441K13Rik antibody Deafness, autosomal dominant 5 antibody Deafness, autosomal dominant 5 protein antibody DFNA5 antibody DFNA5 gene antibody DFNA5_HUMAN antibody Dfna5h antibody EG14210 antibody Fin15 antibody ICERE 1 antibody ICERE-1 antibody Inversely correlated with estrogen receptor expression 1 antibody Non-syndromic hearing impairment protein 5 antibody Nonsyndromic hearing impairment protein antibody
• Abbreviation: GSDME
• CAS Number: 9007-83-4
• Swiss Prot: O60443 Human
• Cellular Locus: Cell membrane, cytosol.
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Recombinant protein within Human DFNA5 aa 34-214 / 496.
• Isotype: IgG1
• Conjugation: Non-conjugated
• Type: Mouse monoclonal Antibody
• Applications: WB, IF-Cell, FC
• Positive Control: Hela cell lysates, HepG2 cell lysates, A431, SiHa, SH-SY5Y.
• Concentration: 2 mg/mL
• Dilution: WB:1:500-1:2,000 ;IF-Cell:1:50-1:100 ;FC:1:50-1:100
• Purity: Protein G affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 55 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No