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DSM265

CAT: 0804-HY-100184-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100184-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of Pf3D7 parasites with an EC50 of 4.3 nM[1][2].
CAS Number
1282041-94-4
UNSPSC
12352005
Hazard Statement
H315, H319, H360
Target
Dihydroorotate Dehydrogenase; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/DSM265.html
Purity
99.92
Solubility
DMSO : 50 mg/mL (ultrasonic) |Ethanol : 11.11 mg/mL (ultrasonic)
Smiles
CC1=NC2=NC(C(C)(F)F)=NN2C(NC3=CC=C(S(F)(F)(F)(F)F)C=C3)=C1
Molecular Formula
C14H12F7N5S
Molecular Weight
415.33
Precautions
H315, H319, H360
References & Citations
[1]Kokkonda S, et al. Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparumDihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. J Med Chem. 2016 Jun 9;59 (11) :5416-31.|[2]Phillips MA, et al. A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med. 2015 Jul 15;7 (296) :296ra111.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Plasmodium

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BA2064-100DSM265
A17069-250DSM265 250mg
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A17069-5DSM265 5mg
A17069-100DSM265 100mg
A17069-50DSM265 50mg
A17069-25DSM265 25mg
A17069-1DSM265 1mg
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