Products for Research Use Only
RegisterLogin

DSM705

CAT: 0804-HY-132171Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-132171Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
DSM705 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs. DSM705 is a potent antimalarial compound[1].
CAS Number
2653225-38-6
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dsm705.html
Solubility
10 mM in DMSO
Smiles
C[C@H](C1=NC=NN1)NC(C2=C(C(C3(C4=CC=C(N=C4)C(F)(F)F)CC3)=CN2)C)=O
Molecular Formula
C19H19F3N6O
Molecular Weight
404.39
References & Citations
[1]Palmer MJ, et, al. Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. J Med Chem. 2021 May 13;64 (9) :6085-6136.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium

Related Products

CatalogName
HY-132170-01DSM502
HY-100184-01DSM265
HY-119057DSM74

Alternative Products

CatalogName
MBS5800560DSM705
MBS5805232DSM705 hydrochloride

Popular Products