UDP-Galactose (disodium)

UDP-Galactose (disodium)

• CAS Number: 137868-52-1
• UNSPSC Description: UDP-Galactose disodium is a natural agonist of the P2Y14 receptor with an EC50 of 0.67 μM for the hP2Y14 receptor. UDP-Galactose disodium is a substrate for the transferase beta-1, 4 galactosyltransferase V (B4GALT5). In addition, UDP-Galactose disodium is required for the biosynthesis of several abundant glycoconjugates that form the surface glycocalyx of Leishmania major[1][2][3].
• Target Antigen: Endogenous Metabolite; P2Y Receptor
• Type: Biochemical Assay Reagents
• Related Pathways: GPCR/G Protein;Metabolic Enzyme/Protease
• Field of Research: Infection; Metabolic Disease; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/udp-galactose-disodium.html
• Purity: 99.42
• Solubility: H2O : 250 mg/mL (ultrasonic)
• Smiles: O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@@H]3[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)(O[Na])=O)(O[Na])=O)O2)NC1=O
• Molecular Weight: 610.27
• References & Citations: [1]Ko H, et al. Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor. J Med Chem. 2007 May 3;50(9):2030-9.|[2]Drabavicius G, Daelemans D. Intermedilysin cytolytic activity depends on heparan sulfates and membrane composition. PLoS Genet. 2021 Feb 12;17(2):e1009387.|[3]Lamerz A C, et al. Deletion of UDP-glucose pyrophosphorylase reveals a UDP-glucose independent UDP-galactose salvage pathway in Leishmania major[J]. Glycobiology, 2010, 20(7): 872-882.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported