UDP-Galactose (disodium)

• UNSPSC Description:

  UDP-Galactose disodium is a natural agonist of the P2Y14 receptor with an EC50 of 0.67 μM for the hP2Y14 receptor. UDP-Galactose disodium is a substrate for the transferase beta-1, 4 galactosyltransferase V (B4GALT5). In addition, UDP-Galactose disodium is required for the biosynthesis of several abundant glycoconjugates that form the surface glycocalyx of Leishmania major[1][2][3].

• Target Antigen:

  Endogenous Metabolite; P2Y Receptor

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  GPCR/G Protein;Metabolic Enzyme/Protease

• Field of Research:

  Infection; Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/udp-galactose-disodium.html

• Purity:

  99.42

• Solubility:

  H2O : 250 mg/mL (ultrasonic)

• Smiles:

  O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@@H]3[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)(O[Na])=O)(O[Na])=O)O2)NC1=O

• Molecular Weight:

  610.27

• References & Citations:

  [1]Ko H, et al. Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor. J Med Chem. 2007 May 3;50(9):2030-9.|[2]Drabavicius G, Daelemans D. Intermedilysin cytolytic activity depends on heparan sulfates and membrane composition. PLoS Genet. 2021 Feb 12;17(2):e1009387.|[3]Lamerz A C, et al. Deletion of UDP-glucose pyrophosphorylase reveals a UDP-glucose independent UDP-galactose salvage pathway in Leishmania major[J]. Glycobiology, 2010, 20(7): 872-882.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported

• CAS Number:

  137868-52-1