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Linifanib

CAT: 0804-HY-50751-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-50751-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Linifanib (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib shows prominent antitumor activity. Linifanib has much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib is a specific miR-10b inhibitor that blocks miR-10b biogenesis[1][2].
CAS Number
796967-16-3
Product Name Alternative
ABT-869; AL-39324
UNSPSC
12352005
Hazard Statement
H361, H372, H410
Target
Apoptosis; Autophagy; c-Fms; c-Kit; FLT3; PDGFR; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/linifanib.html
Purity
99.72
Solubility
DMSO : 13.16 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C2=C3C(N)=NNC3=CC=C2)C=C1)NC4=C(C=CC(C)=C4)F
Molecular Formula
C21H18FN5O
Molecular Weight
375.40
Precautions
H361, H372, H410
References & Citations
[1]Albert DH, et al. Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol Cancer Ther, 2006, 5 (4), 995-1006.|[2]Monroig-Bosque PDC, et al. OncomiR-10b hijacks the small molecule inhibitor linifanib in human cancers. Sci Rep. 2018;8 (1) :13106. Published 2018 Aug 30.|[3]Banchi M, et al. Synergistic activity of linifanib and irinotecan increases the survival of mice bearing orthotopically implanted human anaplastic thyroid cancer. Am J Cancer Res. 2020;10 (7) :2120-2127. Published 2020 Jul 1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1

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