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Norethindrone acetate-d8

CAT: 0804-HY-B1710SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1710SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Norethindrone acetate-d8 is the deuterium labeled Norethindrone acetate. Norethindrone acetate is a female hormone used for the research of endometriosis[1]. Norethindrone acetate-d8 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Name Alternative
19-Norethindrone acetate-D8
UNSPSC
12352211
Target
Isotope-Labeled Compounds; Progesterone Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Others; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology; Inflammation/Immunology; Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@@](C#C)(C([2H])([2H])C[C@@]1([H])[C@@]3([H])[C@]([C@]4([2H])C(C([2H])([2H])C3)=C([2H])C(C([2H])([2H])C4)=O)([H])CC2)OC(C)=O
Molecular Formula
C22H20D8O3
Molecular Weight
348.51
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Muneyyirci-Delale O, et al. Effect of norethindrone acetate in the treatment of symptomatic endometriosis. Int J Fertil Womens Med. 1998 Jan-Feb;43 (1) :24-7.; Kaser DJ, et al. Use of norethindrone acetate alone for postoperative suppression of endometriosis symptoms. J Pediatr Adolesc Gynecol. 2012 Apr;25 (2) :105-8.; Maier WE, et al. Pharmacology and toxicology of ethinyl estradiol and norethindrone acetate in experimental animals. Regul Toxicol Pharmacol. 2001 Aug;34 (1) :53-61.; Cheng DC, et al. Norethindrone acetate inhibition of triglyceride synthesis and release by rat hepatocytes. Atherosclerosis. 1983 Jan;46 (1) :41-8.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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