(+) -Kavain

• Description:

  (+) -Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels[1]. (+) -Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy[2]. (+) -Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied[4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Calcium Channel; GABA Receptor; Sodium Channel

• Type:

  Natural Products

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/__addition__-Kavain.html

• Purity:

  99.98

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C1C=C(OC)C[C@H](/C=C/C2=CC=CC=C2)O1

• Molecular Formula:

  C14H14O3

• Molecular Weight:

  230.26

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Bradić I, et al. [Hirschsprung's disease -- therapy and results]. Acta Chir Iugosl. 1975;22 (2) :183-95.|[2]Chua HC, et al. Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism. PLoS One. 2016 Jun 22;11 (6) :e0157700.|[3]G. Boonen, et al. In vivo Effects of the Kavapyrones (+) -Dihydromethysticin and (±) -Kavain on Dopamine, 3,4-Dihydroxyphenylacetic Acid, Serotonin and 5-Hydroxyindoleacetic Acid Levels in Striatal and Cortical Brain Regions. Planta Medica 64 (1998) 507-510.|[4]Tang X, et al. Kavain Inhibition of LPS-Induced TNF-α via ERK/LITAF. Toxicol Res (Camb) . 2016 Jan 1;5 (1) :188-196.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [500-64-1]