Oleamide

• Background:

  Originally identified in the cerebrospinal fluid of sleep-deprived cats acting as an inducer of physiological sleep in animals (1). Displays agonist activity at cannabinoid CB1 receptors (Ki=8.13 µM) (2). Activates PPARΥ (3). Produces vasodilator effects in rats (4). Displays neuroprotective effects (5) and attenuates sepsis-induced intestinal injury (6).

• Description:

  Endogenous Sleep-inducing Lipid

• Product Name Alternative:

  9Z-Octadecenamide; cis-9-Octadecenamide; Oleic acid amide

• UNSPSC:

  41116105

• Type:

  Inducer

• Source:

  Synthetic

• Field of Research:

  Neuroscience | Neurotransmission | Neurotransmitter Receptors

• Purity:

  >99% (TLC) ; NMR (Conforms)

• Weight:

  0.005

• Format:

  White to off-white powder

• Solubility:

  May be dissolved in DMSO (25 mg/ml); or Ethanol (40 mg/ml)

• Molecular Formula:

  C18H35NO

• Molecular Weight:

  281.5

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. DL Boger et al. 1998 Curr. Pharm. Des. 4:303. 2. JD Leggett et al. 2004 Br. J. Pharmacol. 141:253. 3. M Dionisi et al. 2012 Lipids Health Dis. 11:51. 4. C Hernandez-Diaz et al. 2020 Cannabis Cannabinoid Res. 5:42. 5. M Maya-Lopez et al. 2020 Neurotox. Res. 37:126. 6. Z Zou et al. Mediators Inflamm. 2019 2019:7854389 (eCollection 2019).

• CAS Number:

  301-02-0