TP-808

TP-808

• CAS Number: 852821-06-8
• UNSPSC Description: TP-808 is an intermediate used in tetracycline antibiotic synthesis with antimicrobial activity. TP-808 binds to the 30S ribosome subunit of the bacteria, preventing aminoacyl-trNA from entering the A site, thereby inhibiting the extension of the protein chain. TP-808 can be used in antibiotic drug development research[1].
• Target Antigen: Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/tp-808.html
• Smiles: CC(C)(C)[Si](C)(C)O[C@]12[C@](CC=CC2=O)([H])[C@@H](C3=C(C(OCC4=CC=CC=C4)=NO3)C1=O)N(C)C
• Molecular Weight: 482.64
• References & Citations: [1]Clark RB, et al. Synthesis and biological evaluation of 8-aminomethyltetracycline derivatives as novel antibacterial agents. J Med Chem. 2013 Oct 24;56(20):8112-38.|[2]Zhang W Y, et al. Process research and development of TP-808: a key intermediate for the manufacture of synthetic tetracyclines[J]. Organic Process Research & Development, 2017, 21(3): 377-386.
• Shipping Conditions: Room Temperature