Trichostatin A
CAT:
804-HY-15144-05
Size:
2 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Trichostatin A
- CAS Number: 58880-19-6
- UNSPSC Description: Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC[1].
- Target Antigen: HDAC; Organoid
- Type: Natural Products
- Related Pathways: Cell Cycle/DNA Damage;Epigenetics;Stem Cell/Wnt
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/Trichostatin-A.html
- Solubility: DMSO : 50 mg/mL (ultrasonic)|Methanol : 2 mg/mL (ultrasonic)
- Smiles: CN(C1=CC=C(C=C1)C([C@@H](/C=C(/C=C/C(NO)=O)C)C)=O)C
- Molecular Weight: 302.37
- References & Citations: [1]Vigushin DM et al. Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin Cancer Res. 2001 Apr;7(4):971-6.|[2]Karolczak-Bayatti M, et al. Expression of the GTP-Binding Protein Gαs in Human Myometrial Cells is Regulated by Ubiquitination and Protein Degradation: Involvement of Proteasomal Inhibition by Trichostatin A.,Reprod Sci. 2012 Aug 8.|[3]Hu X, et al. Histone deacetylase inhibitor trichostatin A promotes the osteogenic differentiation of rat adipose-derived stem cells by altering the epigenetic modifications on Runx2 promoter in a BMP signaling-dependent manner.,Stem Cells Dev. 2012 Aug 8.|[4]Azechi T, et al. Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. J Atheroscler Thromb. 2013;20(6):538-47.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported