Pitavastatin (Calcium)

Pitavastatin (Calcium)

• CAS Number: 147526-32-7
• UNSPSC Description: Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin Calcium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects[1][2][3][8].
• Target Antigen: Apoptosis; Autophagy; HMG-CoA Reductase (HMGCR); Mitophagy
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Metabolic Disease; Neurological Disease; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/pitavastatin-calcium.html
• Purity: 99.86
• Solubility: DMSO : ≥ 50 mg/mL
• Smiles: O=C([O-])C[C@H](O)C[C@H](O)/C=C/C1=C(C2=CC=C(F)C=C2)C3=CC=CC=C3N=C1C4CC4.[0.5Ca2+]
• Molecular Weight: 440.49
• References & Citations: [1]Mukhtar RY, et al. Pitavastatin. Int J Clin Pract. 2005 Feb;59(2):239-52.|[2]Kajinami K, et al. Pitavastatin: efficacy and safety profiles of a novel synthetic HMG-CoA reductase inhibitor. Cardiovasc Drug Rev. 2003 Fall;21(3):199-215.|[3]Tajiri K, et al. Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice. Cardiovasc Drugs Ther. 2013 Oct;27(5):413-24.|[4]Hamano T, et al. Pitavastatin decreases tau levels via the inactivation of Rho/ROCK. Neurobiol Aging. 2012 Oct;33(10):2306-20.|[5]de Wolf E, et al.Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer.Sci Rep. 2017 Jul 14;7(1):5410.|[6]Demir B, et al. The Effects of Pitavastatin on Nuclear Factor-Kappa B and ICAM-1 in Human Saphenous Vein Graft Endothelial Culture. Cardiovasc Ther. 2019 May 2;2019:2549432.|[7]Hayashi T, et al. A new HMG-CoA reductase inhibitor, pitavastatin remarkably retards the progression of high cholesterol induced atherosclerosis in rabbits. Atherosclerosis. 2004 Oct;176(2):255-63.|[8]Sahebkar A, et al. A comprehensive review on the lipid and pleiotropic effects of pitavastatin. Prog Lipid Res. 2021 Nov;84:101127.Acta Biochim Biophys Sin (Shanghai). 2024 Apr 25;56(4):621-633.|Antioxidants (Basel). 2024 May 29;13(6):667.|Bioorg Chem. 2024 Apr 16:147:107369.|Research Square Preprint. 2024 Apr 9.|Sci Data. 2024 Sep 19.|Acta Biochim Biophys Sin (Shanghai). 2024 Apr 25;56(4):621-633.|Acta Pharm Sin B. 2020 May;10(5):850-860.|Biochem Pharmacol. 2019 Nov;169:113612. |bioRxiv. 2024 June 11.|J Hepatol. 2021 Aug;75(2):363-376.|Proteomics. 2023 May 4;e2300041.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: Launched