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Pitavastatin-d5 (sodium)

CAT: 0804-HY-B0144AS1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0144AS1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pitavastatin-d5 (sodium) is the deuterium labeled Pitavastatin sodium. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.
Product Name Alternative
NK-104-d5 (sodium)
UNSPSC
12352005
Target
Apoptosis; Autophagy; HMG-CoA Reductase (HMGCR) ; Mitophagy
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease
Field of Research
Cancer; Metabolic Disease
Purity
99.53
Solubility
10 mM in DMSO|DMSO : 100mg/mL (ultrasonic)
Smiles
O=C(O[Na])C[C@H](O)C[C@H](O)/C=C/C1=C(C2=CC=C(F)C=C2)C3=CC=CC=C3N=C1C4([2H])C([2H])([2H])C4([2H])[2H]
Molecular Formula
C25H18D5FNNaO4
Molecular Weight
448.47
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. ; Morikawa S, et al. Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase|[2]Morikawa S, et al. Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells. J Atheroscler Thromb. 2000;7 (3) :138-44.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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