Diphenyleneiodonium chloride
CAT:
804-HY-100965-01
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Diphenyleneiodonium chloride
- CAS Number: 4673-26-1
- UNSPSC Description: Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.
- Target Antigen: NADPH Oxidase; Reactive Oxygen Species; TRP Channel
- Type: Reference compound
- Related Pathways: Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology; Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/Diphenyleneiodonium_chloride.html
- Purity: 99.91
- Solubility: DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : < 0.1 mg/mL (ultrasonic)
- Smiles: C12=CC=CC=C1C3=CC=CC=C3[I+]2.[Cl-]
- Molecular Weight: 314.55
- References & Citations: [1]Suzuki H, et al. The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor. Am J Physiol Cell Physiol. 2014 Aug 15;307(4):C384-94.|[2]He YF, et al. Diphenyleneiodonium protects preoligodendrocytes against endotoxin-activated microglial NADPH oxidase-generated peroxynitrite in a neonatal rat model of periventricular leukomalacia. Brain Res. 2013 Jan 25;1492:108-21.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported