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Enlicitide (chloride)

CAT: 0804-HY-P4153-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-P4153-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Enlicitide chloride is an orally active inhibitor for PCSK9 that blocks the interaction between LPL receptor and PSCK9, with an IC50 of 2.5 nM. Enlicitide chloride can be used in the study of cardiovascular diseases such as atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome or related cardiovascular and cardiometabolic disorders[1][2][3].
CAS Number
2407527-16-4
Product Name Alternative
MK-0616 (chloride)
UNSPSC
12352209
Target
PCSK9
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/enlicitide-chloride.html
Purity
99.63
Solubility
DMSO : 1 mg/mL (ultrasonic; warming)
Smiles
O=C([C@@]1(C)N(C([C@H](CC2=CC=C(OC)C=C2)NC([C@H]([C@@H](C)O)NC3=O)=O)=O)CCC1)NCCC4=CC=C(CN(CCCCCCN5C6=C(C=C(F)C=C6)C7=C5)C(CCC(N[C@@H](C)C(N[C@H](CNC(CCCCC[N+](C)(C)C)=O)C(N[C@H](C(N[C@@H](C7)C(N([C@]38[H])CC[C@@H]8OCC9=O)=O)=O)CC%10=CC(CN9)=CC=C%10)=O)=O)=O)=O)C=C4.[Cl-]
Molecular Formula
C82H110ClFN14O15
Molecular Weight
1586.29
References & Citations
[1]Ding FX, et al. Preparation of cyclic peptides as PCSK9 antagonist compounds: World Intellectual Property Organization, WO2019246349. 2019-12-26.|[2]WHO Drug Information-World Health Organization (WHO) .|[3]Ahamad S, et al., Recent Update on the Development of PCSK9 Inhibitors for Hypercholesterolemia Treatment. J Med Chem. 2022 Dec 8;65 (23) :15513-15539.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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