NLRP3/AIM2-IN-3
CAT:
804-HY-144226-05
Size:
50 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
NLRP3/AIM2-IN-3
- CAS Number: 1787787-60-3
- UNSPSC Description: NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization[1].
- Target Antigen: AIM2; NOD-like Receptor (NLR); Pyroptosis
- Type: Reference compound
- Related Pathways: Apoptosis;Immunology/Inflammation
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/nlrp3-aim2-in-3.html
- Solubility: DMSO : 250 mg/mL (ultrasonic)|Methanol : 50 mg/mL (ultrasonic)
- Smiles: O=C(NC1=CC=CC(O)=C1)CC2=CC3=C(C=C2)C=CN3
- Molecular Weight: 266.29
- References & Citations: [1]Jiao Y, et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022 Feb 11;232:114194.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported