PF-06409577
CAT:
804-HY-103683-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PF-06409577
- CAS Number: 1467057-23-3
- UNSPSC Description: PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.
- Target Antigen: AMPK
- Type: Reference compound
- Related Pathways: Epigenetics;PI3K/Akt/mTOR
- Applications: Metabolism-sugar/lipid metabolism
- Field of Research: Metabolic Disease
- Assay Protocol: https://www.medchemexpress.com/PF-06409577.html
- Purity: 99.44
- Solubility: DMSO : ≥ 100 mg/mL
- Smiles: O=C(C1=CNC2=C1C=C(C3=CC=C(C4(O)CCC4)C=C3)C(Cl)=C2)O
- Molecular Weight: 341.79
- References & Citations: [1]Cameron KO, et al. Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. J Med Chem. 2016 Sep 8;59(17):8068-81.|[2]Salatto CT, et al. Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy. J Pharmacol Exp Ther. 2017 May;361(2):303-311.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: Phase 1