HSV-2 (strain 333) Envelope Glycoprotein C (gC), His Tag (MALS verified)

HSV-2 (strain 333) Envelope Glycoprotein C (gC), His Tag (MALS verified)

• Background: Herpesvirus infections are widely spread throughout the world population. Herpes simplex virus (HSV) belongs to the α-herpesvirus subfamily. There are two main types of HSV, HSV-1 and HSV-2, which infect humans. HSV-2 mainly causes genital lesions, whereas HSV-1 is involved in both oral and genital infections. Glycoprotein C (gC) is a structural component of the herpes simplex virus type 2 (HSV-2) envelope that mediates binding of the virus to cell surface heparan sulfate or chondroitin sulfate. Also plays a role in host immune evasion by inhibiting the host complement cascade activation (By similarity).
• Description: HSV-2 (strain 333) Envelope Glycoprotein C (gC), His Tag (GLC-V52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 102 - Glu 446 (Accession # P06475).
• Specifications: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 39.8 kDa. The protein migrates as 52-62 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expression Region: Leu 102 - Glu 446
• Host: HEK 293
• Target: Glycoprotein C/gC (HSV)
• Conjugation: Unconjugated
• Tag: C-10×His
• Source: HSV-2
• Stability: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Endotoxin: 1.0 EU per μg
• Purity: 90%
• Bioactivity: Immobilized HSV-2 (strain 333) Envelope Glycoprotein C (gC), His Tag (Cat. No. GLC-V52H3) at 5 μg/mL (100 μL/well) can bind Anti-HSV2 gC antibody with a linear range of 0.6-78 ng/mL (QC tested).
• Format: Powder
• Buffer: PBS, pH7.4
• Additives: Trehalose
• Molecular Weight: 39.8 kDa
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C