Human GITR Ligand / TNFSF18 Protein, Fc Tag
CAT:
716-GIL-H526a-1mg
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No




Human GITR Ligand / TNFSF18 Protein, Fc Tag
- Background: Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.
- Description: Human GITR Ligand, Fc Tag (GIL-H526a) is expressed from human 293 cells (HEK293). It contains AA Gln 50 - Ser 177 (Accession # AAH69319.1).
- Specifications: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 41.5 kDa. The protein migrates as 45-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Expression Region: Gln 50 - Ser 177
- Host: HEK 293
- Target: GITR Ligand
- Conjugation: Unconjugated
- Tag: N-Fc
- Source: Human
- Stability: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Endotoxin: 1.0 EU per μg
- Purity: 95%
- Bioactivity: Immobilized Human GITR, His Tag (Cat. No. GIR-H5228) at 2 μg/mL (100 μL/well) can bind Human GITR Ligand, Fc Tag (Cat. No. GIL-H526a) with a linear range of 2-80 ng/mL (QC tested).
- Format: Powder
- Buffer: 50 mM Tris, 100 mM Glycine, pH7.5
- Additives: Trehalose
- Molecular Weight: 41.5 kDa
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C