WAY-100635
CAT:
804-HY-10349-03
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
WAY-100635
- CAS Number: 162760-96-5
- UNSPSC Description: WAY-100635 is a potent and selective 5-HT1A Receptor antagonist with a pIC50 of 8.87, an apparent pA2 of 9.71. WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 is also a potent dopamine D4 receptor agonist[1][2][3].
- Target Antigen: 5-HT Receptor; Dopamine Receptor
- Type: Reference compound
- Related Pathways: GPCR/G Protein;Neuronal Signaling
- Applications: Neuroscience-Neuromodulation
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/way-100635.html
- Purity: 99.51
- Solubility: DMSO : 66.67 mg/mL (ultrasonic)
- Smiles: O=C(N(C1=NC=CC=C1)CCN2CCN(CC2)C3=CC=CC=C3OC)C4CCCCC4
- Molecular Weight: 422.56
- References & Citations: [1]Chemel BR, et al. WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology (Berl). 2006 Oct;188(2):244-51.|[2]Mannucci C, et al. Serotonin involvement in Rhodiola rosea attenuation of nicotine withdrawal signs in rats. Phytomedicine. 2012 Sep 15;19(12):1117-24.|[3]Al Hussainy R, et al. Design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinatedanalogues of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as potential SPECT ligands for the 5-HT1A receptor. J Med Chem. 2011 May 26;54(10):3480-91.Chin J Integr Med. 2019 Nov 29.|Chin Med. 2024 Jun 15;19(1):87.|Int Immunopharmacol. 2024 Jan 16:128:111524.|Nat Neurosci. 2021 Dec 9.|Psychopharmacology (Berl). 2024 Jun 25.|Psychopharmacology. 2022 Sep 15.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported