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α-Conotoxin GID

CAT: 0804-HY-P5147Size: InquireDry Ice: NoHazardous: No
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CAT#:0804-HY-P5147Size:Inquire
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CAS Number
547741-78-6
UNSPSC Description
α-Conotoxin GID is a paralytic peptide neurotoxin and a selective antagonist of nAChR, with IC50s of 5 nM (α7), 3 nM (α3β2)， 150 nM (α4β2), respectively. α-Conotoxin GID is small disulfide-rich peptide, with potential to inhibit chronic pain. α-Conotoxin GID contains a C-terminal carboxylate, thus substitution with a C-terminal carboxamide results in loss of α4β2 nAChR. α-Conotoxin GID can be isolated from the Conus species[1][2][3].
Target Antigen
nAChR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
O=C1[C@@]2([H])N(C[C@@H](C2)O)C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@]3([H])NC([C@@H](NC([C@@]4([H])N(CCC4)C([C@@H](NC([C@@H](NC([C@](NC([C@H](CSSC3)NC([C@H](CC(C(O)=O)C(O)=O)NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](N)[C@@H](C)CC)=O)=O)=O)=O)=O)([H])CSSC[C@H](NC([C@@H](NC([C@@H](N1)CC5=CN=CN5)=O)C(C)C)=O)C(O)=O)=O)CO)=O)CC(N)=O)=O)=O)C)=O)=O)CCCNC(N)=N)=O)C(C)C)=O)CC(N)=O)=O)CC(N)=O)=O
Molecular Weight
2186.39
References & Citations
[1]Armishaw CJ. Synthetic α-conotoxin mutants as probes for studying nicotinic acetylcholine receptors and in the development of novel drug leads. Toxins (Basel). 2010 Jun;2(6):1471-99.|[2]Millard EL, et al. Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. J Biol Chem. 2009 Feb 20;284(8):4944-51.|[3]Nicke A, et al. Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. J Biol Chem. 2003 Jan 31;278(5):3137-44.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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