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Bemnifosbuvir

CAT: 0804-HY-137958A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137958A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bemnifosbuvir (AT-511) is a potent and orally active HCV viral replication inhibitor. Bemnifosbuvir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM) . Bemnifosbuvir has pangenotypic antiviral activity[1][2][3].
CAS Number
1998705-64-8
Product Name Alternative
AT-511
UNSPSC
12352005
Hazard Statement
H301
Target
HCV; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/at-511.html
Purity
99.00
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@](F)(C)[C@H](N2C3=NC(N)=NC(NC)=C3N=C2)O[C@@H]1CO[P@](OC4=CC=CC=C4)(N[C@@H](C)C(OC(C)C)=O)=O
Molecular Formula
C24H33FN7O7P
Molecular Weight
581.53
Precautions
H301
References & Citations
[1]Steven S Good, et al. Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus. PLoS One. 2020 Jan 8;15 (1) :e0227104.|[2]Steven S Good, et al. AT-527, a double prodrug of a guanosine nucleotide analog, is a potent inhibitor of SARS-CoV-2 in vitro and a promising oral antiviral for treatment of COVID-19. Antimicrob Agents Chemother. 2021 Feb 8; AAC.02479-20.|[3]Elina Berliba, et al. Safety, pharmacokinetics and antiviral activity of AT-527, a novel purine nucleotide prodrug, in HCV-infected subjects with and without cirrhosis. Antimicrob Agents Chemother. 2019 Sep 30;63 (12) :e01201-19.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Citation 01
BioRxiv. 2025 Nov 14.|bioRxiv. December 23, 2021.

Chemical Information

Bemnifosbuvir

Bemnifosbuvir is under investigation in clinical trial NCT05629962 (SUNRISE-3: Efficacy and Safety of Bemnifosbuvir in High-risk Outpatients With COVID-19).

CAS Number1998705-64-8
PubChem CID122527275
IUPAC Namepropan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-[2-amino-6-(methylamino)purin-9-yl]-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
Molecular FormulaC24H33FN7O7P
Molecular Weight581.5
XLogP1.7
Topological Polar Surface Area185
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count12
Heavy Atom Count40
Formal Charge0
Complexity919
SMILES
C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=NC3=C(N=C(N=C32)N)NC)(C)F)O)OC4=CC=CC=C4
InChI
InChI=1S/C24H33FN7O7P/c1-13(2)37-21(34)14(3)31-40(35,39-15-9-7-6-8-10-15)36-11-16-18(33)24(4,25)22(38-16)32-12-28-17-19(27-5)29-23(26)30-20(17)32/h6-10,12-14,16,18,22,33H,11H2,1-5H3,(H,31,35)(H3,26,27,29,30)/t14-,16+,18+,22+,24+,40-/m0/s1
InChIKey
OISLSHLAXHALQZ-LZEIJKKFSA-N
Chemical Structure
2D Structure
2D structure of Bemnifosbuvir
CAS: 1998705-64-8
CID: 122527275
Formula: C24H33FN7O7P
MW: 581.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight581.5
XLogP31.7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count12
Exact Mass581.21631158
Monoisotopic Mass581.21631158
Topological Polar Surface Area185 Ų
Heavy Atom Count40
Formal Charge0
Complexity919
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3617141-01Bemnifosbuvir
T9331-01Bemnifosbuvir hemisulfate
464809Bemnifosbuvir free base
C01427-25mgBemnifosbuvir Hemisulfate (AT-527)

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