H-L-Tyr(2-azidoethyl)-OH (hydrochloride)

H-L-Tyr(2-azidoethyl)-OH (hydrochloride)

• CAS Number: 1567845-62-8
• UNSPSC Description: H-L-Tyr(2-azidoethyl)-OH hydrochloride is a unnatural Tyrosine derivative. H-L-Tyr(2-azidoethyl)-OH hydrochloride is a click chemistry reagent containing an azide group[1][2]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
• Target Antigen: ADC Linker
• Type: Reference compound
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/h-l-tyr-2-azidoethyl-oh-hydrochloride.html
• Solubility: H2O : 11.67 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: OC([C@@H](N)CC1=CC=C(C=C1)OCCN=[N+]=[N-])=O.Cl
• Molecular Weight: 286.71
• References & Citations: [1]Maza JC, et al. Synthesis and Incorporation of Unnatural Amino Acids To Probe and Optimize Protein Bioconjugations. Bioconjug Chem. 2015 Sep 16;26(9):1884-9.|[2]Tookmanian EM, et al. Azidoethoxyphenylalanine as a Vibrational Reporter and Click Chemistry Partner in Proteins. Chemistry. 2015 Dec 21;21(52):19096-103.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported