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A-971432

CAT: 0804-HY-110291-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110291-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A-971432 is a potent, selective and orally active sphingosine-1-phosphate (S1P) receptor 5 agonist with IC50s of .362, >10, 0.006 μM for S1P1, S1P3, S1P5 respectively. A-971432 protects blood–brain barrier (BBB) homeostasis. A-971432 reverses age-related cognitive decline. A-971432 has the potential for the research of alzheimer’s disease or multiple sclerosis [1][2].
CAS Number
1240308-45-5
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a-971432.html
Purity
99.0
Solubility
DMSO : 3 mg/mL (ultrasonic; warming)
Smiles
O=C(C1CN(C1)CC2=CC=C(C=C2)OCC3=CC=C(C(Cl)=C3)Cl)O
Molecular Formula
C18H17Cl2NO3
Molecular Weight
366.24
Precautions
H315, H319, H335
References & Citations
[1]1、Hobson AD, et al. Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders. J Med Chem. 2015 Dec 10;58 (23) :9154-70.|[2]Di Pardo A, et al. Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood-brain barrier integrity and exerts therapeutic effect in an animal model of Huntington's disease. Hum Mol Genet. 2018 Jul 15;27 (14) :2490-2501.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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