Lupanine (perchlorate)

Lupanine (perchlorate)

• CAS Number: 7400-11-5
• UNSPSC Description: Lupanine (D-Lupanine) perchlorate is a natural ketonic derivative of Sparteine ((+)-Sparteine (HY-W008350)) with a ganglioplegic activity. Lupanine perchlorate shows binding affinity for nicotinic receptor (nAChR) with a Ki value of 500 nM[1].
• Target Antigen: nAChR
• Type: Natural Products
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/lupanine-perchlorate.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N2[C@]([C@](C3)([H])CN(CCCC4)[C@]4([H])[C@]3([H])C2)([H])CCC1.O=Cl(=O)(O)=O
• Molecular Weight: 348.82
• References & Citations: [1]K Yovo, et al. Comparative pharmacological study of sparteine and its ketonic derivative lupanine from seeds of Lupinus albus. Planta Med. 1984 Oct;50(5):420-4.|[2]Green BT, et al. Anagyrine desensitization of peripheral nicotinic acetylcholine receptors. A potential biomarker of quinolizidine alkaloid teratogenesis in cattle. Res Vet Sci. 2017 Dec;115:195-200.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported