TMRM Perchlorate

• Description:

  Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms[1].

• Product Name Alternative:

  T668

• UNSPSC:

  12171500

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Fluorescent Dye

• Type:

  Dye Reagents

• Related Pathways:

  Others

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/TMRM_Perchlorate.html

• Purity:

  99.69

• Solubility:

  DMSO : 41.67 mg/mL (ultrasonic)

• Smiles:

  O=C (C1=CC=CC=C1C2=C3C=CC (N (C) C) =CC3=[O+]C4=C2C=CC (N (C) C) =C4) OC.O=Cl (=O) ([O-]) =O

• Molecular Formula:

  C25H25ClN2O7

• Molecular Weight:

  500.93

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Chowdhury SR, et al. Simultaneous evaluation of substrate-dependent oxygen consumption rates and mitochondrial membrane potential by TMRM and safranin in cortical mitochondria. Biosci Rep. 2015 Dec 8;36 (1) :e00286.|[2]Monteith A, et al. Imaging of mitochondrial and non-mitochondrial responses in cultured rat hippocampal neurons exposed to micromolar concentrations of TMRM. PLoS One. 2013;8 (3) :e58059.|[3]Crowley LC, et al. Measuring Mitochondrial Transmembrane Potential by TMRE Staining. Cold Spring Harb Protoc. 2016 Dec 1;2016 (12) :pdb.prot087361.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Dye Reagents

• Clinical Information:

  No Development Reported

• Citation 01:

  AAPS J. 2025 Jun 13;27 (4) :109.|ACS Nano. 2025 Mar 11;19 (9) :9390-9411.|Acta Pharmacol Sin. 2025 Sep 1.|Adv Mater. 2024 May;36 (22) :e2211609.|Bioact Mater. 2024 Oct 30:44:447-460.|Biochim Biophys Acta Mol Cell Res. 2025 Jan 27:119911.|Cell Metab. 2025 Oct 7;37 (10) :2076-2092.e8.|Cell Rep Med. 2025 Mar 18;6 (3) :102020.|Cell Signal. 2020 Nov;75:109733.|Exp Eye Res. 2021 Aug:209:108640.|Fish Shellfish Immunol. 2025 Jun:161:110275.|Inflammation. 2025 Jan 10.|Int Immunopharmacol. 2025 Mar 26:150:114266.|J Adv Res. 2025 Aug:74:609-620.|Mater Today Bio. 2025 Oct 30:35:102483.|Mol Cancer. 2025 Jan 28;24 (1) :34.|Phytomedicine. 2025 Apr:139:156517.|Redox Biol. 2025 Sep 22:87:103877.|Stem Cell Res Ther. 2025 May 1;16 (1) :222.|Adv Sci (Weinh) . 2023 Mar;10 (7) :e2203869.|Aquaculture. 5 October 2022, 738900.|Autophagy. 2021 Nov;17 (11) :3592-3606.|Basic Res Cardiol. 2024 Feb;119 (1) :113-131.|Biochem Biophys Res Commun. 2022 Sep 17:621:130-136.|Cell Signal. 2024 Jan:113:110969.|Endocrinology. 2020 Sep 1;161 (9) :bqaa119.|Int J Mol Sci. 2023 Jul 17;24 (14) :11554.|J Thromb Haemost. 2021 Dec;19 (12) :3113-3125.|Mol Cell. 2025 Apr 3;85 (7) :1395-1410.e5.|Redox Rep. 2025 Dec;30 (1) :2536400.|Toxicon. 2022 Sep:216:28-36.

• CAS Number:

  115532-50-8