MMP8 (Cleaved-Leu101) rabbit pAb

MMP8 (Cleaved-Leu101) rabbit pAb

• Description: Catalytic activity: Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3. 4. 24. 7, this enzyme cleaves type III collagen more slowly than type I. Cofactor: Binds 2 zinc ions per subunit. Cofactor: Binds 3 calcium ions per subunit. Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. enzyme regulation: Cannot be activated without removal of the activation peptide. function: Can degrade fibrillar type I, II, and III collagens. similarity: Belongs to the peptidase M10A family. similarity: Contains 4 hemopexin-like domains. subcellular location: Stored in intracellular granules. tissue specificity: Neutrophils.
• Synonyms: Neutrophil collagenase (EC 3.4.24.34;Matrix metalloproteinase-8;MMP-8;PMNL collagenase;PMNL-CL)
• Gene ID: 4317
• UniProt: P22894
• Cellular Locus: Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Stored in intracellular granules.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthesized peptide derived from human MMP8 (Cleaved-Leu101)
• Clonality: Polyclonal
• Validated Applications: WB, IHC
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:500-2000;IHC-p 1:50-300
• Molecular Weight: 40 53kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.