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Propofol-d17

CAT: 0804-HY-B0649S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0649S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Propofol-d17 is the deuterium labeled Propofol. Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties[1].
CAS Number
1261393-54-7
UNSPSC
12352005
Hazard Statement
H225, H301+H311+H331, H370
Target
Endogenous Metabolite; GABA Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
98.90
Solubility
10 mM in DMSO
Smiles
C(C([2H])([2H])[2H])(C([2H])([2H])[2H])(C1=C(O)C(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])=C(C(=C1[2H])[2H])[2H])[2H]
Molecular Formula
C12HD17O
Molecular Weight
195.38
Precautions
H225, H301+H311+H331, H370
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]R Nadeson, et al. Antinociceptive Properties of Propofol: Involvement of Spinal Cord Gamma-Aminobutyric acid (A) Receptors. J Pharmacol Exp Ther . 1997 Sep;282 (3) :1181-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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