Propofol-d17

• Description :

  Propofol-d17 is the deuterium labeled Propofol. Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H225, H301+H311+H331, H370

• Target :

  Endogenous Metabolite; GABA Receptor

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Purity :

  98.90

• Solubility :

  10 mM in DMSO

• Smiles :

  C(C([2H])([2H])[2H])(C([2H])([2H])[2H])(C1=C(O)C(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])=C(C(=C1[2H])[2H])[2H])[2H]

• Molecular Formula :

  C12HD17O

• Molecular Weight :

  195.38

• Precautions :

  H225, H301+H311+H331, H370

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]R Nadeson, et al. Antinociceptive Properties of Propofol: Involvement of Spinal Cord Gamma-Aminobutyric acid (A) Receptors. J Pharmacol Exp Ther . 1997 Sep;282 (3) :1181-6.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1261393-54-7]