Propofol

• Description :

  Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic[1].

• CAS Number :

  [2078-54-8]

• Product Name Alternative :

  2,6-Diisopropylphenol

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Endogenous Metabolite; GABA Receptor

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/propofol.html

• Concentration :

  10mM

• Purity :

  99.52

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 0.5 mg/mL (ultrasonic)

• Smiles :

  OC1=C(C(C)C)C=CC=C1C(C)C

• Molecular Formula :

  C12H18O

• Molecular Weight :

  178.27

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]R Nadeson, et al. Antinociceptive Properties of Propofol: Involvement of Spinal Cord Gamma-Aminobutyric acid (A) Receptors. J Pharmacol Exp Ther . 1997 Sep;282 (3) :1181-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched