Mca-SEVNLDAEFK(Dnp)-NH2

Mca-SEVNLDAEFK(Dnp)-NH2

• CAS Number: 1802078-32-5
• UNSPSC Description: Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1[1].
• Target Antigen: Fluorescent Dye
• Type: Peptides
• Related Pathways: Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/mca-sevnldaefk-dnp-nh2.html
• Purity: 98.96
• Solubility: DMSO : 1.25 mg/mL (ultrasonic)
• Smiles: [O-][N+](C(C=C(C=C1)[N+]([O-])=O)=C1NCCCC[C@@H](C(N)=O)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CO)NC(CC(C3=CC=C(OC)C=C3O4)=CC4=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
• Molecular Weight: 1532.52
• References & Citations: [1]Koike H, et.al. Thimet oligopeptidase cleaves the full-length Alzheimer amyloid precursor protein at a beta-secretase cleavage site in COS cells. J Biochem. 1999 Jul;126(1):235-42.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported